ARG57754
anti-TPMT antibody
anti-TPMT antibody for ICC/IF,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TPMT |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TPMT |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-245 of Human TPMT (NP_000358.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Thiopurine methyltransferase; Thiopurine S-methyltransferase; EC 2.1.1.67 |
应用说明
| 预测反应性说明 | Mouse | ||||||
|---|---|---|---|---|---|---|---|
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | K562 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TPMT |
| 全名 | thiopurine S-methyltransferase |
| 背景介绍 | This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014] |
| 生物功能 | Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 预测分子量 | 28 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG57754 anti-TPMT antibody ICC/IF image
Immunofluorescence: U2OS cells stained with ARG57754 anti-TPMT antibody.
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ARG57754 anti-TPMT antibody WB image
Western blot: 25 µg of K562 cell lysate stained with ARG57754 anti-TPMT antibody at 1:1000 dilution.
