ARG52456
anti-TPH1 antibody
anti-TPH1 antibody for IHC-Frozen sections,Western blot and Human,Rat
Cancer antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody
概述
| 产品描述 | Sheep Polyclonal antibody recognizes TPH1 |
|---|---|
| 反应物种 | Hu, Rat |
| 预测物种 | Mamm |
| 应用 | IHC-Fr, WB |
| 宿主 | Sheep |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TPH1 |
| 抗原物种 | Rabbit |
| 抗原 | Recombinant rabbit tryptophan hydroxylase, isolated as inclusion bodies from E. coli and purified by preparative SDS-PAGE |
| 偶联标记 | Un-conjugated |
| 別名 | Tryptophan 5-hydroxylase 1; TRPH; EC 1.14.16.4; Tryptophan 5-monooxygenase 1; TPRH |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | Specific for the ~55k tryptophan hydroxylase protein. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| 稳定剂 | 0.1 mg/ml BSA, 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TPH1 |
| 全名 | tryptophan hydroxylase 1 |
| 背景介绍 | Tryptophan hydroxylase (TPH) catalyzes the first step in the biosynthesis of serotonin and melatonin (Martinez et al., 2001). Thus, expression of TPH can be used as an indicator of the localization of serotonin and melatonin in brain. In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland (Haycock et al., 2002) . Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis (Martinez et al., 2001). |
| 研究领域 | Cancer antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody |
| 预测分子量 | 51 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG52456 anti-TPH1 antibody WB image
Western blot: Human dorsal Raphe nucleus showing specific immunolabeling of the ~55 kDa tryptophan hydroxylase protein stained with ARG52456 anti-TPH1 antibody.
