ARG41886
anti-TP53BP2 / ASPP2 antibody
anti-TP53BP2 / ASPP2 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TP53BP2 / ASPP2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TP53BP2 / ASPP2 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 360-600 of Human TP53BP2 / ASPP2. (NP_001026855.2) |
| 偶联标记 | Un-conjugated |
| 別名 | P53BP2; Renal carcinoma antigen NY-REN-51; p53-binding protein 2; ASPP2; Tumor suppressor p53-binding protein 2; Apoptosis-stimulating of p53 protein 2; p53BP2; 53BP2; Bcl2-binding protein; PPP1R13A; Bbp; BBP |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q13625 Human Apoptosis-stimulating of p53 protein 2 |
|---|---|
| 基因名称 | TP53BP2 |
| 全名 | tumor protein p53 binding protein 2 |
| 背景介绍 | This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. [UniProt] |
| 细胞定位 | Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42. [UniProt] |
| 预测分子量 | 126 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG41886 anti-TP53BP2 / ASPP2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse brain tissue stained with ARG41886 anti-TP53BP2 / ASPP2 antibody 1:100 dilution.
