ARG46575
anti-TMEM106A antibody
anti-TMEM106A antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TMEM106A |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TMEM106A |
| 抗原物种 | Human |
| 抗原 | A 14 amino acid synthetic peptide within the last 50 amino acids of human TMEM106A. |
| 偶联标记 | Un-conjugated |
| 別名 | TMEM106A; Transmembrane protein 106A |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -625°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TMEM106A |
| 全名 | transmembrane protein 106A |
| 背景介绍 | Predicted to be involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of macromolecule biosynthetic process; and positive regulation of nitric oxide metabolic process. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] |
| 生物功能 | Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (PubMed:29131025, PubMed:30456879). [UniProt] |
| 细胞定位 | Cell membrane; Cell membrane . [UniProt] |
| 预测分子量 | 29 kDa |
