ARG45113
anti-TLR6 antibody
anti-TLR6 antibody for ICC/IF and Human
概述
| 产品描述 | Goat Polyclonal antibody recognizes TLR6 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TLR6 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to C-terminus of Human TLR6 protein. |
| 偶联标记 | Un-conjugated |
| 別名 | CD286; toll-like receptor 6; TLR6 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TLR6 |
| 全名 | Toll-like receptor (TLR) |
| 背景介绍 | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011] |
| 生物功能 | Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. [UniProt] |
| 细胞定位 | Cell membrane. Cytoplasmic vesicle, phagosome membrane, Membrane raft, Golgi apparatus [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG45113 anti-TLR6 antibody ICC/IF
Immunofluorescence: A549 cells stained with ARG45113 anti-TLR6 antibody at 10μg/ml dilution.
