ARG59145
anti-TLR5 antibody
anti-TLR5 antibody for IHC-Formalin-fixed paraffin-embedded sections and Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TLR5 |
|---|---|
| 反应物种 | Rat |
| 预测物种 | Hu, Ms |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TLR5 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to 16 aa of Human TLR5. (within aa. 450 - 500) |
| 偶联标记 | Un-conjugated |
| 別名 | Toll/interleukin-1 receptor-like protein 3; MELIOS; TIL3; SLEB1; Toll-like receptor 5; SLE1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Rat brain |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | TLR5 |
|---|---|
| 全名 | toll-like receptor 5 |
| 背景介绍 | This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009] |
| 生物功能 | Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 98 kDa |
| 翻译后修饰 | Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines. Phosphorylated at Tyr-798 upon flagellin binding; required for signaling. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG59145 anti-TLR5 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat brain stained with ARG59145 anti-TLR5 antibody at 10 µg/ml dilution.
