anti-TLE1 antibody [SQab22275]

anti-TLE1 antibody [SQab22275] for IHC-Formalin-fixed paraffin-embedded sections and Human


产品描述 Recombinant Rabbit Monoclonal antibody [SQab22275] recognizes TLE1
反应物种 Hu
应用 IHC-P
宿主 Rabbit
克隆 Monoclonal
克隆号 SQab22275
同位型 IgG
靶点名称 TLE1
抗原物种 Human
抗原 Full length protein corresponding to Human TLE1.
偶联标记 Un-conjugated
Protein Full name Transducin-like enhancer protein 1
別名 ESG; ESG1; GRG1; TLE-1; Enhancer of split groucho-like protein 1; E(Sp1) homolog; Transducin-like enhancer protein 1


应用 推荐稀释比
IHC-P1:100 - 1:200
应用说明 IHC-P: Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer (pH 9.0). Incubate the samples at RT (18-25°C) for 30 min.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 Human synovial sarcoma


形式 Liquid
纯化 Purification with Protein A.
缓冲液 PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA.
抗菌剂 0.01% Sodium azide
稳定剂 40% Glycerol and 0.05%BSA
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.



GeneID: 7088 Human TLE1

Swiss-port # Q04724 Human Transducin-like enhancer protein 1

基因名称 TLE1
全名 TLE family member 1, transcriptional corepressor
背景介绍 Enables identical protein binding activity and transcription corepressor activity. Involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of anoikis; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]
生物功能 Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity).
The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
细胞定位 Nucleus
预测分子量 83.2 kDa
翻译后修饰 Phosphoprotein, Ubl conjugation

检测图片 (1) Click the Picture to Zoom In

  • ARG66945 anti-TLE1 antibody [SQab22275] IHC-P image

    Immunohistochemistry: Formalin/PFA-fixed and paraffin-embedded sections of Human synovial sarcoma stained with ARG66945 anti-TLE1 antibody [SQab22275]. Antigen Retrieval: Heat tissue section in Tris-EDTA buffer (pH 9.0).