ARG66945
anti-TLE1 antibody [SQab22275]
anti-TLE1 antibody [SQab22275] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Recombinant Rabbit Monoclonal antibody [SQab22275] recognizes TLE1 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab22275 |
| 同位型 | IgG |
| 靶点名称 | TLE1 |
| 抗原物种 | Human |
| 抗原 | Full length protein corresponding to Human TLE1. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Transducin-like enhancer protein 1 |
| 別名 | ESG; ESG1; GRG1; TLE-1; Enhancer of split groucho-like protein 1; E(Sp1) homolog; Transducin-like enhancer protein 1 |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer (pH 9.0). Incubate the samples at RT (18-25°C) for 30 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| 阳性对照 | Human synovial sarcoma |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05%BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q04724 Human Transducin-like enhancer protein 1 |
|---|---|
| 基因名称 | TLE1 |
| 全名 | TLE family member 1, transcriptional corepressor |
| 背景介绍 | Enables identical protein binding activity and transcription corepressor activity. Involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of anoikis; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022] |
| 生物功能 | Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. |
| 细胞定位 | Nucleus |
| 预测分子量 | 83.2 kDa |
| 翻译后修饰 | Phosphoprotein, Ubl conjugation |
检测图片 (1) Click the Picture to Zoom In
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ARG66945 anti-TLE1 antibody [SQab22275] IHC-P image
Immunohistochemistry: Formalin/PFA-fixed and paraffin-embedded sections of Human synovial sarcoma stained with ARG66945 anti-TLE1 antibody [SQab22275]. Antigen Retrieval: Heat tissue section in Tris-EDTA buffer (pH 9.0).
