ARG66945
anti-TLE1 antibody [SQab22275]
anti-TLE1 antibody [SQab22275] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
产品描述 | Recombinant Rabbit Monoclonal antibody [SQab22275] recognizes TLE1 |
---|---|
反应物种 | Hu |
应用 | IHC-P |
宿主 | Rabbit |
克隆 | Monoclonal |
克隆号 | SQab22275 |
同位型 | IgG |
靶点名称 | TLE1 |
抗原物种 | Human |
抗原 | Full length protein corresponding to Human TLE1. |
偶联标记 | Un-conjugated |
Protein Full name | Transducin-like enhancer protein 1 |
別名 | ESG; ESG1; GRG1; TLE-1; Enhancer of split groucho-like protein 1; E(Sp1) homolog; Transducin-like enhancer protein 1 |
应用说明
应用建议 |
|
||||
---|---|---|---|---|---|
应用说明 | IHC-P: Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer (pH 9.0). Incubate the samples at RT (18-25°C) for 30 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
||||
阳性对照 | Human synovial sarcoma |
属性
形式 | Liquid |
---|---|
纯化 | Purification with Protein A. |
缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA. |
抗菌剂 | 0.01% Sodium azide |
稳定剂 | 40% Glycerol and 0.05%BSA |
存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
数据库连接 |
Swiss-port # Q04724 Human Transducin-like enhancer protein 1 |
---|---|
基因名称 | TLE1 |
全名 | TLE family member 1, transcriptional corepressor |
背景介绍 | Enables identical protein binding activity and transcription corepressor activity. Involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of anoikis; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022] |
生物功能 | Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. |
细胞定位 | Nucleus |
预测分子量 | 83.2 kDa |
翻译后修饰 | Phosphoprotein, Ubl conjugation |
检测图片 (1) Click the Picture to Zoom In