ARG45385
anti-TIE1 antibody [6F12]
anti-TIE1 antibody [6F12] for Flow cytometry,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody [6F12] recognizes TIE1 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 6F12 |
| 同位型 | IgG1 |
| 靶点名称 | TIE1 |
| 抗原物种 | Human |
| 抗原 | Recombinant Human TIE1. |
| 偶联标记 | Un-conjugated |
| 別名 | TIE; Tyrosine-protein kinase receptor Tie-1; JTK14; EC 2.7.10.1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G chromatography |
| 缓冲液 | PBS |
| 浓度 | 0.1 - 1.0 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P35590 Human Tyrosine-protein kinase receptor Tie-1 |
|---|---|
| 基因名称 | TIE1 |
| 全名 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 |
| 背景介绍 | This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] |
| 生物功能 | Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | ~ 125 kDa |
| 翻译后修饰 | Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG45385 anti-TIE1 antibody [6F12] WB image
Western blot: TIE1 recombinant protein stained with ARG45385 anti-TIE1 antibody [6F12].
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ARG45385 anti-TIE1 antibody [6F12] FACS image
Flow Cytometry: Human umbilical vein endothelial stained with ARG45385 anti-TIE1 antibody [6F12] at 1-5 μg/ml dilution.
