ARG58773
anti-TIA1 antibody [TRIA1-1]
anti-TIA1 antibody [TRIA1-1] for Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody [TRIA1-1] recognizes TIA1 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | TRIA1-1 |
| 同位型 | IgG2b |
| 靶点名称 | TIA1 |
| 抗原物种 | Human |
| 抗原 | Recombinant partial protein corresponding to aa. 279-380 of Human TIA1. |
| 偶联标记 | Un-conjugated |
| 別名 | T-cell-restricted intracellular antigen-1; WDM; TIA-1; RNA-binding protein TIA-1; p40-TIA-1; Nucleolysin TIA-1 isoform p40 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | ~ 44 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 0.1 mg/ml BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TIA1 |
| 全名 | TIA1 cytotoxic granule-associated RNA binding protein |
| 背景介绍 | The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq, Jul 2008] |
| 生物功能 | Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. [UniProt] |
| 细胞定位 | Cytoplasmic granule, Nucleus. [UniProt] |
| 预测分子量 | 43 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG58773 anti-TIA1 antibody [TRIA1-1] WB image
Western blot: HepG2, PC3 and HeLa cell lysates stained with ARG58773 anti-TIA1 antibody [TRIA1-1]. The long and short forms differ by 17 amino acids.
