ARG44350
anti-THRAP3 antibody
anti-THRAP3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes THRAP3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | THRAP3 |
| 抗原物种 | Human |
| 抗原 | Human THRAP3 recombinant fusion protein (a.a. sequence: 340-500). |
| 偶联标记 | Un-conjugated |
| 別名 | THRAP3; Thyroid Hormone Receptor Associated Protein 3; TRAP150; BCLAF2; BCLAF1 And THRAP3 Family Member 2; Thyroid Hormone Receptor-Associated Protein Complex 150 KDa Component; Thyroid Hormone Receptor-Associated Protein 3; TR-Associated Protein, 150-KDa; Thyroid Hormone Receptor-Associated Protein, 150 KDa Subunit; Trap150 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS, 0.01% Thimerosal and 50% Glycerol. |
| 抗菌剂 | 0.01% Thimerosal |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | THRAP3 |
| 全名 | Thyroid Hormone Receptor Associated Protein 3 |
| 背景介绍 | Enables phosphoprotein binding activity; thyroid hormone receptor binding activity; and transcription coactivator activity. Involved in nuclear-transcribed mRNA catabolic process; positive regulation of circadian rhythm; and regulation of RNA metabolic process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nuclear speck. Part of mediator complex. Colocalizes with exon-exon junction complex. |
| 生物功能 | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes. |
| 细胞定位 | Nucleus |
| 预测分子量 | 109 kDa |
| 翻译后修饰 | Acetylation, ADP-ribosylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation |
检测图片 (4) Click the Picture to Zoom In
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ARG44350 anti-THRAP3 antibody IHC-P image
Immunohistochemistry: Human brain stained with ARG44350 anti-THRAP3 antibody at 1:100 dilution.
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ARG44350 anti-THRAP3 antibody WB image
Western blot: HeLa stained with ARG44350 anti-THRAP3 antibody at 1:1000 dilution.
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ARG44350 anti-THRAP3 antibody IHC-P image
Immunohistochemistry: Rat brain stained with ARG44350 anti-THRAP3 antibody at 1:100 dilution.
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ARG44350 anti-THRAP3 antibody IHC-P image
Immunohistochemistry: Mouse brain stained with ARG44350 anti-THRAP3 antibody at 1:100 dilution.
