ARG43198
anti-THNSL2 / SOFAT antibody
anti-THNSL2 / SOFAT antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes THNSL2 / SOFAT |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | THNSL2 / SOFAT |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide within the center region of Human THNSL2 / SOFAT. |
| 偶联标记 | Un-conjugated |
| 別名 | Threonine synthase-like 2; Secreted osteoclastogenic factor of activated T-cells; EC 4.2.3.-; SOFAT; TSH2; THS2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HepG2, Raw264.7 and H9C2 | ||||
| 实际分子量 | ~ 54 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | 0.42% Potassium phosphate (pH 7.3), 0.87% NaCl, 0.01% Sodium azide and 30% Glycerol. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 30% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | THNSL2 |
| 全名 | threonine synthase-like 2 |
| 背景介绍 | This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] |
| 生物功能 | [Isoform 1]: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity). [Isoform SOFAT]: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions. [UniProt] |
| 细胞定位 | Isoform SOFAT: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent pathway. [UniProt] |
| 预测分子量 | 54 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG43198 anti-THNSL2 / SOFAT antibody WB image
Western blot: HepG2, Raw264.7 and H9C2 whole cell lysates stained with ARG43198 anti-THNSL2 / SOFAT antibody.
