ARG56078

anti-TGF beta antibody [1D11.16.8]

anti-TGF beta antibody [1D11.16.8] for ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Neutralizing,Western blot and Human,Mouse,Rat,Cow,Dog,Hamster,Monkey

publication_link 参考文献1

概述

产品描述 Mouse Monoclonal antibody [1D11.16.8] recognizes TGF beta
反应物种 Hu, Ms, Rat, Cow, Dog, Hm, Mk
应用 ELISA, ICC/IF, IHC-P, Neut, WB
特异性 This mAb recognizes TGF beta 1, 2 and 3.
宿主 Mouse
克隆 Monoclonal
克隆号 1D11.16.8
同位型 IgG1, kappa
靶点名称 TGF beta
抗原物种 Bovine
抗原 Bovine TGF-beta2 protein.
偶联标记 Un-conjugated
別名 TGF-beta2; Cetermin; LDS4; Polyergin; Glioblastoma-derived T-cell suppressor factor; G-TSF; Transforming growth factor beta-2; LAP; TGF-beta-2; BSC-1 cell growth inhibitor

应用说明

应用建议
应用 推荐稀释比
ELISA0.1-0.4 μg/ml (detect); 2-8 μg/ml (capture)
ICC/IF8-25 μg/ml
IHC-P8-25 μg/ml
NeutAssay-dependent
WB1-2 μg/ml (under non-reducing conditions only)
应用说明 WB: It is recommended detct TGF beta under non-reducing conditions.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式 Liquid
纯化 Purification with Protein G.
缓冲液 PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA
抗菌剂 0.05% Sodium azide
稳定剂 0.1 mg/ml BSA
浓度 0.2 mg/ml
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 21808 Mouse TGFB2

GeneID: 7042 Human TGFB2

GeneID: 81809 Rat TGFB2

基因名称 TGFB2
全名 transforming growth factor, beta 2
背景介绍 This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
生物功能 TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. [UniProt]
细胞定位 Cytoplasm and extracellular (secreted)
预测分子量 48 kDa
翻译后修饰 The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive.

文献引用

Mouse Astrocytes Promote Microglial Ramification by Releasing TGF-β and Forming Glial Fibers.

Neutralizing / Mouse

Jinqiang Zhang et al.
Front Cell Neurosci.,  (2020)

publication_link

 

hr_line