ARG64569
anti-TFEB antibody
anti-TFEB antibody for Western blot and Human
Controls and Markers antibody; Gene Regulation antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes TFEB |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Dog |
| 应用 | WB |
| 特异性 | This antibody is expected not to cross-react to TFE3 and MITF. |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TFEB |
| 抗原物种 | Human |
| 抗原 | C-QKDLQKSRELENH |
| 偶联标记 | Un-conjugated |
| 別名 | Class E basic helix-loop-helix protein 35; BHLHE35; ALPHATFEB; bHLHe35; TCFEB; Transcription factor EB |
应用说明
| 应用建议 |
|
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|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TFEB |
| 全名 | transcription factor EB |
| 生物功能 | Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. [UniProt] |
| 研究领域 | Controls and Markers antibody; Gene Regulation antibody |
| 预测分子量 | 53 kDa |
| 翻译后修饰 | Sumoylated; does not affect dimerization with MITF. |
检测图片 (1) Click the Picture to Zoom In
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ARG64569 anti-TFEB antibody WB image
Western Blot: Human Lung lysate (35 µg protein in RIPA buffer) stained with ARG64569 anti-TFEB antibody at 1 µg/ml dilution.
