ARG55431
anti-TERF2IP / RAP1 antibody
anti-TERF2IP / RAP1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Controls and Markers antibody; Gene Regulation antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TERF2IP / RAP1 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Mk |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TERF2IP / RAP1 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 349-378 (C-terminus) of Human TERF2IP. |
| 偶联标记 | Un-conjugated |
| 別名 | Telomeric repeat-binding factor 2-interacting protein 1; TRF2-interacting telomeric protein 1; RAP1; DRIP5; RAP1 homolog; hRap1; Dopamine receptor-interacting protein 5; Repressor/activator protein 1 homolog; TERF2-interacting telomeric protein 1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | HepG2 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9NYB0 Human Telomeric repeat-binding factor 2-interacting protein 1 |
|---|---|
| 基因名称 | TERF2IP |
| 全名 | telomeric repeat binding factor 2, interacting protein |
| 背景介绍 | The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010] |
| 生物功能 | Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. [UniProt] |
| 细胞定位 | Nucleus. Cytoplasm. Chromosome. Chromosome, telomere. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex (By similarity). |
| 研究领域 | Controls and Markers antibody; Gene Regulation antibody |
| 预测分子量 | 44 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG55431 anti-TERF2IP / RAP1 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human breast carcinoma stained with ARG55431 anti-TERF2IP / RAP1 antibody.
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ARG55431 anti-TERF2IP / RAP1 antibody WB image
Western blot: 35 µg of HepG2 cell lysate stained with ARG55431 anti-TERF2IP / RAP1 antibody.
