ARG64788

anti-TDP43 antibody

Datasheet

参考文献1

订购信息

包装

价格 (USD)

100 μg

499

arigo in CHINA:
恩瑞科生物
☎ 400-886-0853,
0571-8708-1890

概述

产品描述	Goat Polyclonal antibody recognizes TDP43
反应物种	Hu
预测物种	Ms, Rat, Cow, Dog, Pig
应用	IHC-P, WB
宿主	Goat
克隆	Polyclonal
同位型	IgG
靶点名称	TDP43
抗原物种	Human
抗原	C-HISNAEPKHNSNRQ
偶联标记	Un-conjugated
別名	TAR DNA-binding protein 43; TDP-43; ALS10

应用说明

应用建议

应用	推荐稀释比
IHC-P	5 µg/ml
WB	0.3 - 1 µg/ml

应用说明

WB: Recommend incubate at RT for 1h.
IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0).
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purified from goat serum by antigen affinity chromatography.
缓冲液	Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA.
抗菌剂	0.02% Sodium azide
稳定剂	0.5% BSA
浓度	0.5 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 23435 Human TARDBP Swiss-port # Q13148 Human TAR DNA-binding protein 43
背景介绍	HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
研究领域	Gene Regulation antibody; Microbiology and Infectious Disease antibody; Neuroscience antibody
预测分子量	45 kDa
翻译后修饰	Hyperphosphorylated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU. Ubiquitinated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU. Cleaved to generate C-terminal fragments in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.

检测图片 (3) Click the Picture to Zoom In

ARG64788 anti-TDP43 antibody WB image

Western blot: Jurkat lysate (35 µg protein in RIPA buffer) stained with ARG64788 anti-TDP43 antibody at 0.3 µg/ml dilution.
ARG64788 anti-TDP43 antibody WB image

Western blot: Human Cerebellum (A), Frontal Cotex (B) and Hippocampus (C) lysates (35 µg protein in RIPA buffer) stained with ARG64788 anti-TDP43 antibody at 1 µg/ml dilution.
ARG64788 anti-TDP43 antibody IHC-P image

Immunohistochemistry: Paraffin-embedded Human prostate tissue. Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). The tissue section was stained with ARG64788 anti-TDP43 antibody at 5 µg/ml dilution followed by AP-staining.