ARG66509
anti-TCL1 antibody
anti-TCL1 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes TCL1 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1, kappa |
| 靶点名称 | TCL1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human TCL1. |
| 偶联标记 | Un-conjugated |
| 別名 | Protein p14 TCL1; Oncogene TCL1; T-cell leukemia/lymphoma protein 1A; TCL1; Oncogene TCL-1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Citric acid buffer (pH 6.0) was used. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.5% BSA |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P56279 Human T-cell leukemia/lymphoma protein 1A |
|---|---|
| 基因名称 | TCL1A |
| 全名 | T-cell leukemia/lymphoma 1A |
| 背景介绍 | Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010] |
| 生物功能 | Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Note=Microsomal fraction. [UniProt] |
| 预测分子量 | 13 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG66509 anti-TCL1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human follicular lymphoma stained with ARG66509 anti-TCL1 antibody at 1:200 (4°C, overnight). Antigen Retrieval: Citric acid buffer (pH 6.0) was used.
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ARG66509 anti-TCL1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human tonsil stained with ARG66509 anti-TCL1 antibody at 1:200 (4°C, overnight). Antigen Retrieval: Citric acid buffer (pH 6.0) was used.
