ARG63181
anti-TBL1X / TBL1XR1 antibody
anti-TBL1X / TBL1XR1 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Cancer antibody; Gene Regulation antibody; Metabolism antibody; Neuroscience antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes TBL1X / TBL1XR1 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Cow, Dog |
| 应用 | IHC-P |
| 特异性 | This antibody is also expected to recognise the human protein TBLR1 (NP_078941), which is very similar. Variants (NP_005638.1; NP_001132938.1) encode isoform a (TBL1X) and variants (NP_001132939.1; NP_001132940.1 ) encode isoform b (TBLX1). |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TBL1X / TBL1XR1 |
| 抗原物种 | Human |
| 抗原 | SASDGSVCVLDLRK |
| 偶联标记 | Un-conjugated |
| 別名 | Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linked; EBI; SMAP55; TBL1; F-box-like/WD repeat-containing protein TBL1X |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Steam tissue section in Tris/EDTA buffer (pH 9.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O60907 Human F-box-like/WD repeat-containing protein TBL1X |
|---|---|
| 基因名称 | TBL1X |
| 全名 | transducin (beta)-like 1X-linked |
| 背景介绍 | The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq, Nov 2008] |
| 生物功能 | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. [UniProt] |
| 研究领域 | Cancer antibody; Gene Regulation antibody; Metabolism antibody; Neuroscience antibody |
| 预测分子量 | 62 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG63181 anti-TBL1X / TBL1XR1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human kidney tissue. Antigen Retrieval: Steam tissue section in Tris/EDTA buffer (pH 9.0). The tissue section was stained with ARG63181 anti-TBL1X / TBL1XR1 antibody at 4 µg/ml dilution followed by HRP-staining.
