ARG43638
anti-TAL1 antibody
anti-TAL1 antibody for Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TAL1 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TAL1 |
| 抗原物种 | Mouse |
| 抗原 | Synthetic peptide within a.a 150-200 of Mouse TAL1 protein. |
| 偶联标记 | Un-conjugated |
| Protein Full name | T-cell acute lymphocytic leukemia protein 1 |
| 別名 | tal-1; SCL; TCL5; bHLHa17; Class A basic helix-loop-helix protein 17; T-cell leukemia/lymphoma protein 5; Stem cell protein; T-cell acute lymphocytic leukemia protein 1; TAL-1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | 35-50 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% Sodium azide. |
| 抗菌剂 | 0.09% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P17542 Human T-cell acute lymphocytic leukemia protein 1 Swiss-port # P22091 Mouse T-cell acute lymphocytic leukemia protein 1 homolog |
|---|---|
| 基因名称 | Tal1 |
| 全名 | T cell acute lymphocytic leukemia 1 |
| 背景介绍 | Enables several functions, including DNA-binding transcription factor activity; E-box binding activity; and histone deacetylase binding activity. Involved in several processes, including myeloid cell differentiation; positive regulation of cellular component organization; and positive regulation of erythrocyte differentiation. Located in chromatin and nucleoplasm. Part of transcription regulator complex. Implicated in acute lymphoblastic leukemia. [provided by Alliance of Genome Resources, Apr 2022] |
| 生物功能 | Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). [UniProt] |
| 细胞定位 | Nucleus |
| 预测分子量 | 34 kDa |
| 翻译后修饰 | Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity). Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity). [UniProt] |
