ARG46549
anti-TAB3 antibody
anti-TAB3 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TAB3 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TAB3 |
| 抗原物种 | Human |
| 抗原 | A 13 amino acid synthetic peptide within the last 50 amino acids of human TAB3. |
| 偶联标记 | Un-conjugated |
| 別名 | TAB3; TAB-3; MAP3K7IP3; NAP1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; NF-kappa-B-activating protein 1; TGF-beta-activated kinase 1-binding protein 3; TAK1-binding protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 纯化 | Affinity chromatography purified |
|---|---|
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8N5C8 Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
|---|---|
| 基因名称 | TAB3 |
| 全名 | TGF-beta activated kinase 1/MAP3K7 binding protein 3 |
| 背景介绍 | The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| 生物功能 | Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. [From Uniprot] |
| 预测分子量 | 79 kDa |
| 翻译后修饰 | Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment. |
