ARG52434
anti-Synaptojanin 1 antibody [5H1]
anti-Synaptojanin 1 antibody [5H1] for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Rat
Neuroscience antibody
概述
| 产品描述 | Mouse Monoclonal antibody [5H1] recognizes Synaptojanin 1 |
|---|---|
| 反应物种 | Rat |
| 应用 | IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 5H1 |
| 同位型 | IgG1 |
| 靶点名称 | Synaptojanin 1 |
| 抗原物种 | Rat |
| 抗原 | Recombinant protein from the C-terminal region of rat synaptojanin 1. |
| 偶联标记 | Un-conjugated |
| 別名 | PARK20; Synaptojanin-1; EC 3.1.3.36; Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1; INPP5G |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | Specific for the ~145k synaptojanin I protein in Western blots of Rat brain extracts. Immunolabeling blocked by preadsorption of antibody with the protein used to geneRate the antibody. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| 稳定剂 | 0.1 mg/ml BSA, 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SYNJ1 |
| 全名 | synaptojanin 1 |
| 背景介绍 | Synaptojanin is a phosphatidylinositol phosphatase involved in clathrinmediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms; one that is ~ 145 kDA and is exclusively expressed in neurons, and the other ~ 170 kDa which is expressed in non-neuronal, peripheral tissues (Ramjaun AR & McPherson PS, 1996). The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Down’s syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidylinositol-4,5- bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice (Voronov SV et al., 2008). |
| 研究领域 | Neuroscience antibody |
| 预测分子量 | 173 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG52434 anti-Synaptojanin 1 antibody [5H1] WB image
Western Blot: rat hippocampal lysate showing specific immunolabeling of the ~145k synaptojanin I protein stained with Synaptojanin 1 antibody [5H1] (ARG52434).
