anti-Synapsin 1 phospho (Ser9) antibody
anti-Synapsin 1 phospho (Ser9) antibody for ICC/IF,IHC-Frozen sections,Western blot and Human,Mouse,Rat
|产品描述||Rabbit Polyclonal antibody recognizes Synapsin 1 phospho (Ser9)|
|反应物种||Hu, Ms, Rat|
|应用||ICC/IF, IHC-Fr, WB|
|抗原||Phosphospecific peptide around Ser9 (R-L-S(p)-D-S) of Human Synapsin 1.|
|別名||SYNI; Brain protein 4.1; Synapsin-1; SYN1a; SYN1b; Synapsin I|
|应用说明||* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.|
|纯化||Antibodies were produced by immunizing rabbits with KLH-conjugated synthetic phosphopeptide. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. In addition, non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.|
|缓冲液||PBS (without Mg2+ and Ca2+, pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol.|
|抗菌剂||0.02% Sodium azide|
|存放说明||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|注意事项||For laboratory research only, not for drug, diagnostic or other use.|
|背景介绍||This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]|
|生物功能||Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. [UniProt]|
|翻译后修饰||Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal.
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.
检测图片 (2) Click the Picture to Zoom In
ARG51751 anti-Synapsin 1 phospho (Ser9) antibody ICC/IF image
Immunofluorescence: Methanol-fixed HeLa cells stained with ARG51751 anti-Synapsin 1 phospho (Ser9) antibody.
ARG51751 anti-Synapsin 1 phospho (Ser9) antibody WB image
Western blot: Extracts from Mouse brain tissue stained with ARG51751 anti-Synapsin 1 phospho (Ser9) antibody.