ARG67047

anti-Survivin antibody [SQab30320]

anti-Survivin antibody [SQab30320] for IHC-Formalin-fixed paraffin-embedded sections and Human

概述

产品描述 Recombinant rabbit Monoclonal antibody [SQab30320] recognizes Survivin
反应物种 Hu
应用 IHC-P
宿主 Rabbit
克隆 Monoclonal
克隆号 SQab30320
同位型 IgG
靶点名称 Survivin
抗原物种 Human
抗原 Synthetic peptide of Human Survivin.
偶联标记 Un-conjugated
Protein Full name Baculoviral IAP repeat-containing protein 5
別名 BIRC5, Baculoviral IAP Repeat Containing 5, Apoptosis Inhibitor 4, EPR-1, API4, Baculoviral IAP Repeat-Containing Protein 5, Apoptosis Inhibitor Survivin, Survivin, Baculoviral IAP Repeat-Containing 5, IAP4

应用说明

应用建议
应用 推荐稀释比
IHC-P1:50 - 1:100
应用说明 The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 Human tonsil

属性

形式 Liquid
纯化 Purification with Protein A.
缓冲液 PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA.
抗菌剂 0.01% Sodium azide
稳定剂 40% Glycerol and 0.05%BSA
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 332 Human BIRC5

Swiss-port # O15392 Human Baculoviral IAP repeat-containing protein 5

基因名称 BIRC5
全名 Baculoviral IAP Repeat Containing 5
背景介绍 This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
生物功能 Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesi. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. [Uniprot]
细胞定位 Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule, Nucleus
预测分子量 16 kDa
翻译后修饰 Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting. [UniProt]

检测图片 (1) Click the Picture to Zoom In

  • ARG67047 anti-Survivin antibody [SQab30320] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded human tonsil stained with ARG67047 anti-Survivin antibody [SQab30320].