ARG45527
anti-Sprouty 4 / Spry-4 antibody
anti-Sprouty 4 / Spry-4 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Sprouty 4 / Spry-4 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Sprouty 4 / Spry-4 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human Sprouty 4 / Spry-4. |
| 偶联标记 | Un-conjugated |
| 別名 | SPRY4; Sprouty RTK Signaling Antagonist 4; Protein Sprouty Homolog 4; Sprouty Homolog 4 (Drosophila); Sprouty Homolog 4; Spry-4; HH17 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 实际分子量 | 35 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SPRY4 |
| 全名 | Sprouty RTK Signaling Antagonist 4 |
| 背景介绍 | This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014] |
| 生物功能 | Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. [UniProt] |
| 细胞定位 | Cell membrane; Cell projection; Cytoplasm. [UniProt] |
| 预测分子量 | 33 kDa |
| 翻译后修饰 | Acetylation; Phosphoprotein. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG45527 anti-Sprouty 4 / Spry-4 antibody IHC-P image
Immunohistochemistry: Human liver cancer stained with ARG45527 anti-Sprouty 4 / Spry-4 antibody at 2 μg/ml dilution.
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ARG45527 anti-Sprouty 4 / Spry-4 antibody WB image
Western blot: PC-3 stained with ARG45527 anti-Sprouty 4 / Spry-4 antibody at 0.5 μg/ml dilution.
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ARG45527 anti-Sprouty 4 / Spry-4 antibody FACS image
Flow Cytometry: PC-3 stained with ARG45527 anti-Sprouty 4 / Spry-4 antibody at 1 µg/10^6 cells dilution.
