ARG67020
anti-Somatostatin antibody
anti-Somatostatin antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat
Controls and Markers antibody; Developmental Biology antibody; Neuroscience antibody
概述
| 产品描述 | Recombinant Rabbit Polyclonal antibody recognizes Somatostatin |
|---|---|
| 反应物种 | Hu, Rat |
| 预测物种 | Ms |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Somatostatin |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to N-terminal region of Human Somatostatin. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Somatostatin |
| 別名 | Somatostatin; Growth hormone release-inhibiting factor |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer (pH 8.0). Incubate the samples at RT (18-25°C) for 42 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
||||||
| 阳性对照 | Human Gastric fundus tissue; A549 | ||||||
| 实际分子量 | ~15-17 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5%BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.5%BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SST |
| 全名 | somatostatin |
| 背景介绍 | The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008] |
| 生物功能 | Somatostatin-14 Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. Neuronostatin May enhance low-glucose-induced glucagon release by pancreatic alpha cells. This effect may be mediated by binding to GPR107 and PKA activation. May regulate cardiac contractile function. May compromise cardiomyocyte viability. In the central nervous system, may impair memory retention and may affect hippocampal excitability. May also have anxiolytic and anorexigenic effects. May play a role in arterial pressure regulation. May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH. [UniProt] |
| 细胞定位 | Secreted |
| 研究领域 | Controls and Markers antibody; Developmental Biology antibody; Neuroscience antibody |
| 预测分子量 | 13 kDa |
| 翻译后修饰 | Amidation; Cleavage on pair of basic residues; Disulfide bond |
检测图片 (2) Click the Picture to Zoom In
-
ARG67020 anti-Somatostatin antibody IHC-P image
Immunohistochemistry: Paraffin-embedded sections of Human Gastric fundus tissue stained with ARG67020 anti-Somatostatin antibody. Antigen Retrieval: Heat tissue section in Tris-EDTA buffer (pH 8.0).
-
ARG67020 anti-Somatostatin antibody WB image
Western blot: A549 lysate stained with ARG67020 anti-Somatostatin antibody.
