ARG44288
anti-Slingshot homolog 1 / SSH1 (Ser978) antibody
anti-Slingshot homolog 1 / SSH1 (Ser978) antibody for ICC/IF,Western blot and Human,Mouse,Rat,Chicken
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Slingshot homolog 1 / SSH1 phospho (Ser978) |
|---|---|
| 反应物种 | Hu, Ms, Rat, Chk |
| 应用 | ICC/IF, WB |
| 特异性 | This antibody recognize Slingshot homolog 1 / SSH1 isoform L. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SSH1 |
| 抗原物种 | Human |
| 抗原 | Synthetic phospho-peptide |
| 偶联标记 | Un-conjugated |
| 別名 | SSH1; Slingshot Protein Phosphatase 1; SSH1L; KIAA1298; Protein Phosphatase Slingshot Homolog 1; SSH-Like Protein 1; HSSH-1L; Slingshot Homolog 1 (Drosophila); Slingshot Homolog 1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Antigen Affinity Purified |
| 缓冲液 | PBS with 1 mg/ml BSA, 0.05% Sodium azide and 50% glycerol |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 1 mg/ml BSA and 50% glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q76I79 Mouse Protein phosphatase Slingshot homolog 1 Swiss-port # Q8WYL5 Human Protein phosphatase Slingshot homolog 1 |
|---|---|
| 基因名称 | SSH1 |
| 全名 | Slingshot Protein Phosphatase 1 |
| 背景介绍 | The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| 生物功能 | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. |
| 细胞定位 | Cell projection, Cytoplasm, Cytoskeleton |
| 预测分子量 | 116 kDa |
| 翻译后修饰 | Acetylation, Phosphoprotein |
检测图片 (2) Click the Picture to Zoom In
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ARG44288 anti-Slingshot homolog 1 / SSH1 (Ser978) antibody IHC-P image
Immunohistochemistry: PC12 stained with ARG44288 anti-Slingshot homolog 1 / SSH1 (Ser978) antibody.
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ARG44288 anti-Slingshot homolog 1 / SSH1 (Ser978) antibody WB image
Western blot: PC12 stained with ARG44288 anti-Slingshot homolog 1 / SSH1 (Ser978) antibody.
