ARG44609
anti-Siglec 10 antibody [5G6] (APC)
anti-Siglec 10 antibody [5G6] (APC) for Flow cytometry and Human
概述
| 产品描述 | APC-conjugated Mouse Monoclonal antibody recognizes Siglec 10 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 5G6 |
| 同位型 | IgG1 |
| 靶点名称 | Siglec 10 |
| 抗原物种 | Human |
| 抗原 | SIGLEC10 extracellular domain fused with human IgG1 Fc fragment |
| 偶联标记 | APC |
| 別名 | SIGLEC10; Sialic Acid Binding Ig Like Lectin 10; SLG2; SIGLEC-10; PRO940; Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7; Sialic Acid-Binding Ig-Like Lectin 10; Siglec-Like Protein 2; Siglec-Like Gene 2; MGC126774; Sialic Acid Binding Ig-Like Lectin 10; Siglec-10 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified antibody is conjugated with activated allophycocyanin (APC), and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q96LC7 Human Sialic acid-binding Ig-like lectin 10 |
|---|---|
| 基因名称 | SIGLEC10 |
| 全名 | sialic acid binding Ig-like lectin 10 |
| 背景介绍 | SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002] |
| 生物功能 | During initiation of adaptive immune responses by CD8-alpha+ dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification. [UniProt] |
| 细胞定位 | Cell membrane, Membrane, Secreted. [UniProt] |
| 预测分子量 | 77 kDa |
| 翻译后修饰 | Disulfide bond, Glycoprotein, Phosphoprotein. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG44609 anti-Siglec 10 antibody [5G6] (APC) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG44609 anti-Siglec 10 antibody [5G6] (APC) at 10 μl/ 100 μl dilution.
