ARG11146
anti-Serotonin Transporter antibody
anti-Serotonin Transporter antibody for IHC-Frozen sections and Human,Mouse,Rat,Cow
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Serotonin Transporter |
|---|---|
| 反应物种 | Hu, Ms, Rat, Cow |
| 应用 | IHC-Fr |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Serotonin Transporter |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide of Human Serotonin Transporter. (KSITPETPTEIPCGDIRLNAV) |
| 偶联标记 | Un-conjugated |
| 別名 | SERT; 5HTT; SERT1; Sodium-dependent serotonin transporter; hSERT; 5-HTTLPR; Solute carrier family 6 member 4; HTT; 5-HTT; 5HT transporter; OCD1 |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS, 5 mM Sodium azide and 50% Glycerol. |
| 抗菌剂 | 5 mM Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SLC6A4 |
| 全名 | solute carrier family 6 (neurotransmitter transporter), member 4 |
| 背景介绍 | This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019] |
| 生物功能 | Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Could be part of recycling endosomes (PubMed:18227069, PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity). Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858) (PubMed:18227069). [UniProt] |
| 预测分子量 | 70 kDa |
| 翻译后修饰 | Glycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms. Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation. Phosphorylation upon PKC stimulation modifies the SERT distribution and density in the membrane, and diminishes the uptake capacity. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
-
ARG11146 anti-Serotonin Transporter antibody IHC-Fr image
Immunohistochemistry: Frozen section of Rat brain tissue stained with ARG11146 anti-Serotonin Transporter antibody (green), and co-stained with ARG11150 anti-Tyrosine Hydroxylase antibody (red). The blue stain reveals DNA in cell nuclei.
