ARG41871
anti-SUZ12 antibody
anti-SUZ12 antibody for ICC/IF,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SUZ12 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SUZ12 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 470-739 of Human SUZ12. (NP_056170.2) |
| 偶联标记 | Un-conjugated |
| 別名 | Polycomb protein SUZ12; Chromatin precipitated E2F target 9 protein; ChET 9 protein; CHET9; Joined to JAZF1 protein; JJAZ1; Suppressor of zeste 12 protein homolog |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | HeLa | ||||||||
| 实际分子量 | ~ 100 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SUZ12 |
| 全名 | SUZ12 polycomb repressive complex 2 subunit |
| 背景介绍 | This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009] |
| 生物功能 | Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 83 kDa |
| 翻译后修饰 | Sumoylated, probably by PIAS2. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG41871 anti-SUZ12 antibody ICC/IF image
Immunofluorescence: C6 cells stained with ARG41871 anti-SUZ12 antibody at 1:100 dilution.
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ARG41871 anti-SUZ12 antibody WB image
Western blot: 25 µg of HeLa cell lysate stained with ARG41871 anti-SUZ12 antibody at 1:1000 dilution.
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ARG41871 anti-SUZ12 antibody IP image
Immunoprecipitation: 200 µg extracts of HeLa cells were immunoprecipitated and stained with ARG41871 anti-SUZ12 antibody at 1:500 dilution.
