概述

产品描述	Rabbit Polyclonal antibody recognizes SUZ12
反应物种	Hu, Ms, Rat
应用	FACS, ICC/IF, IP, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	SUZ12
抗原物种	Human
抗原	Synthetic peptide of Human SUZ12.
偶联标记	Un-conjugated
別名	Polycomb protein SUZ12; Chromatin precipitated E2F target 9 protein; ChET 9 protein; CHET9; Joined to JAZF1 protein; JJAZ1; Suppressor of zeste 12 protein homolog

应用说明

应用建议	应用 推荐稀释比 FACS Assay-dependent ICC/IF 1:50 - 1:200 IP 1:50 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	SW480
实际分子量	~ 87 kDa

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 23512 Human SUZ12 GeneID: 52615 Mouse SUZ12 Swiss-port # Q15022 Human Polycomb protein SUZ12 Swiss-port # Q80U70 Mouse Polycomb protein Suz12
基因名称	SUZ12
全名	SUZ12 polycomb repressive complex 2 subunit
背景介绍	This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]
生物功能	Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. [UniProt]
细胞定位	Nucleus. [UniProt]
预测分子量	83 kDa
翻译后修饰	Sumoylated, probably by PIAS2. [UniProt]

检测图片 (1) Click the Picture to Zoom In