概述

产品描述	Rabbit Polyclonal antibody recognizes SUMO4
反应物种	Hu, Ms, Rat
应用	FACS, ICC/IF, IP, WB
特异性	This antibody might also reacts to SUMO2 and SUMO3 based on high sequence homology.
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	SUMO4
抗原物种	Human
抗原	Synthetic peptide derived from Human SUMO4
偶联标记	Un-conjugated
別名	SUMO-4; IDDM5; SMT3H4; dJ281H8.4; Small ubiquitin-related modifier 4; Small ubiquitin-like protein 4

应用说明

应用建议	应用 推荐稀释比 FACS 1:50 ICC/IF 1:50 - 1:200 IP 1:50 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	293T
实际分子量	~ 16 kDa

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 387082 Human SUMO4 Swiss-port # Q6EEV6 Human Small ubiquitin-related modifier 4
基因名称	SUMO4
全名	small ubiquitin-like modifier 4
背景介绍	This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]
生物功能	Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. [UniProt]
预测分子量	11 kDa
翻译后修饰	In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. [UniProt]

检测图片 (1) Click the Picture to Zoom In