ARG45104
anti-STRADB/PAPK antibody
anti-STRADB/PAPK antibody for Western blot and Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes STRADB/PAPK. |
|---|---|
| 反应物种 | Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | STRADB |
| 抗原物种 | Mouse |
| 抗原 | Synthetic peptide corresponding to amino acids from the C-terminal region of mouse STRADB/PAPK protein. |
| 偶联标记 | Un-conjugated |
| 別名 | STRADB; STE20 Related Adaptor Beta; CALS-21; ILPIP; ALS2CR2; ILPIPA; PAPK; Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein; Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 2; STE20-Related Kinase Adapter Protein Beta; STE20-Related Kinase Adaptor Beta; seudokinase ALS2CR2; STRAD Beta; ILP-Interacting Protein ILPIPA; ILP-Interacting Protein; PRO1038 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Antigen Affinity Purified. |
| 缓冲液 | PBS, 0.02% NaN3 |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8K4T3 Mouse STE20-related kinase adapter protein beta |
|---|---|
| 基因名称 | Stradb |
| 全名 | STE20 Related Adaptor Beta |
| 背景介绍 | This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this ge |
| 生物功能 | Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. [Uniprot] |
| 细胞定位 | Cytoplasm, Nucleus. [Uniprot] |
| 预测分子量 | 48 kDa |
