ARG55448
anti-STK39 / SPAK antibody
anti-STK39 / SPAK antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Metabolism antibody; Signaling Transduction antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes STK39 / SPAK |
|---|---|
| 反应物种 | Hu, Ms |
| 预测物种 | Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | STK39 / SPAK |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 346-376 (Center) of Human SPAK. |
| 偶联标记 | Un-conjugated |
| 別名 | SPAK; STE20/SPS1-related proline-alanine-rich protein kinase; Ste-20-related kinase; Serine/threonine-protein kinase 39; EC 2.7.11.1; PASK; DCHT |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | 293 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9UEW8 Human STE20/SPS1-related proline-alanine-rich protein kinase Swiss-port # Q9Z1W9 Mouse STE20/SPS1-related proline-alanine-rich protein kinase |
|---|---|
| 基因名称 | STK39 |
| 全名 | serine threonine kinase 39 |
| 背景介绍 | This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008] |
| 生物功能 | May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. Note=Nucleus when caspase-cleaved. |
| 研究领域 | Metabolism antibody; Signaling Transduction antibody |
| 预测分子量 | 59 kDa |
| 翻译后修饰 | Phosphorylated at Ser-309 by PRKCQ. |
检测图片 (2) Click the Picture to Zoom In
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ARG55448 anti-STK39 / SPAK antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human cancer tissue stained with ARG55448 anti-STK39 / SPAK antibody.
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ARG55448 anti-STK39 / SPAK antibody WB image
Western blot: 35 µg of 293 cell lysate stained with ARG55448 anti-STK39 / SPAK antibody at 1:1000 dilution.
