anti-STAT6 antibody [SQab22264]

anti-STAT6 antibody [SQab22264] for IHC-Formalin-fixed paraffin-embedded sections and Human

Gene Regulation antibody; Signaling Transduction antibody


产品描述 Recombinant Rabbit Monoclonal antibody [SQab22264] recognizes STAT6
反应物种 Hu
应用 IHC-P
宿主 Rabbit
克隆 Monoclonal
克隆号 SQab22264
同位型 IgG
靶点名称 STAT6
抗原物种 Human
抗原 A synthetic peptide corresponding to the sequence of human Stat6.
偶联标记 Un-conjugated
Protein Full name Signal transducer and activator of transcription 6
別名 D12S1644; STAT6B; STAT6C; Signal transducer and activator of transcription 6; IL-4-STAT; IL-4 Stat


应用 推荐稀释比
IHC-P1:100 - 1:200
应用说明 IHC-P: Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer (pH 9.0). Incubate the samples at RT (18-25°C) for 30 min.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 Human solitary fibrous tumor (SFT) tissue


形式 Liquid
纯化 Purification with Protein A.
缓冲液 PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA.
抗菌剂 0.01% Sodium azide
稳定剂 40% Glycerol and 0.05%BSA
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.



GeneID: 6778 Human STAT6

Swiss-port # P42226 Human Signal transducer and activator of transcription 6

基因名称 STAT6
全名 signal transducer and activator of transcription 6, interleukin-4 induced
背景介绍 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
生物功能 Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. [UniProt]
研究领域 Gene Regulation antibody; Signaling Transduction antibody
预测分子量 94 kDa
翻译后修饰 Tyrosine phosphorylated following stimulation by IL4/interleukin-4 and IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling.

检测图片 (1) Click the Picture to Zoom In

  • ARG66935 anti-STAT6 antibody [SQab22264] IHC-P image

    Immunohistochemistry: Formalin/PFA-fixed and paraffin-embedded sections of Human solitary fibrous tumor (SFT) tissue stained with ARG66935 anti-STAT6 antibody [SQab22264]. Antigen Retrieval: Heat tissue section in Tris-EDTA buffer (pH 9.0).