概述

产品描述	Mouse Monoclonal antibody recognizes SSB
反应物种	Hu
应用	WB
特异性	This antibody detects endogenous levels of SSB and does not cross-react with related proteins.
宿主	Mouse
克隆	Monoclonal
同位型	IgG1
靶点名称	SSB
抗原物种	Human
抗原	Purified recombinant Human SSB protein fragments expressed in E. coli.
偶联标记	Un-conjugated
別名	LARP3; Sjoegren syndrome type B antigen; La; La ribonucleoprotein; Lupus La protein; La autoantigen; La/SSB; SS-B

应用说明

应用建议	应用 推荐稀释比 WB 1:1000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 0.03% Proclin300 and 50% Glycerol.
抗菌剂	0.03% Proclin300
稳定剂	50% Glycerol
浓度	2.6 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 6741 Human SSB Swiss-port # P05455 Human Lupus La protein
基因名称	SSB
全名	Sjogren syndrome antigen B (autoantigen La)
背景介绍	The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
生物功能	Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. [UniProt]
细胞定位	Nucleus.
预测分子量	47 kDa
翻译后修饰	Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein. The N-terminus is blocked.

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