ARG67219
anti-SRY / TDF antibody
anti-SRY / TDF antibody for Western blot and Bovine
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SRY / TDF |
|---|---|
| 反应物种 | Bov |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 靶点名称 | SRY / TDF |
| 抗原物种 | Bovine |
| 抗原 | Recombinant fragment corresponding to aa. M1-Y229 of Bovine SRY / TDF. |
| 偶联标记 | Un-conjugated |
| 別名 | SRY; Sex Determining Region Y; TDF; Sex-Determining Region Y Protein; Testis-Determining Factor; Essential Protein For Sex Determination In Human Males; Testis-Determining Factor On Y; Sex-Determining Region On Y; SRXX1; SRXY1; TDY |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS |
| 浓度 | 0.1 - 1.0 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SRY |
| 全名 | Sex Determining Region Y |
| 背景介绍 | This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008] |
| 生物功能 | Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing |
| 细胞定位 | Cytoplasm; Nucleus. [UniProt] |
| 预测分子量 | 27 kDa |
| 翻译后修饰 | Acetylation. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG67219 anti-SRY / TDF antibody WB image
Western blot: SRY / TDF recombinant protein stained with ARG67219 anti-SRY / TDF antibody.
