ARG41388
anti-SPRY2 / Sprouty 2 antibody
anti-SPRY2 / Sprouty 2 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SPRY2 / Sprouty 2 |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SPRY2 / Sprouty 2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human SPRY2 / Sprouty 2. |
| 偶联标记 | Un-conjugated |
| 別名 | Protein sprouty homolog 2; hSPRY2; Spry-2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 实际分子量 | ~ 42 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SPRY2 |
| 全名 | sprouty RTK signaling antagonist 2 |
| 背景介绍 | This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008] |
| 生物功能 | May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. [UniProt] |
| 细胞定位 | Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor). [UniProt] |
| 预测分子量 | 35 kDa |
| 翻译后修饰 | Cleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro). [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG41388 anti-SPRY2 / Sprouty 2 antibody WB image
Western blot: HeLa cell lysate stained with ARG41388 anti-SPRY2 / Sprouty 2 antibody.
