ARG46520
anti-SPINK2 antibody
anti-SPINK2 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SPINK2 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SPINK2 |
| 抗原物种 | Mouse |
| 抗原 | A 16 amino acid synthetic peptide within the last 50 amino acids of mouse SPINK2. |
| 偶联标记 | Un-conjugated |
| 別名 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor); SPINK2; HUSI-II; Serine protease inhibitor Kazal-type 2; Acrosin-trypsin inhibitor |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 18 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -570°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | SPINK2 |
|---|---|
| 全名 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) |
| 背景介绍 | Predicted to enable serine-type endopeptidase inhibitor activity. Involved in acrosome assembly. Acts upstream of or within several processes, including male germ cell proliferation; negative regulation of serine-type endopeptidase activity; and seminiferous tubule development. Located in acrosomal vesicle and neuron projection. Is expressed in intestine; male reproductive gland or organ; oviduct; skin; and tongue. Human ortholog(s) of this gene implicated in spermatogenic failure 29. Orthologous to human SPINK2 (serine peptidase inhibitor Kazal type 2). [provided by Alliance of Genome Resources, Jul 2025] |
| 生物功能 | As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:21705336, PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (PubMed:21705336). It also inhibits trypsin (PubMed:21705336). [UniProt] |
| 细胞定位 | Secreted; Cytoplasm; Cytoplasmic vesicle. [UniProt] |
| 预测分子量 | 15 kDa |
| 翻译后修饰 | Disulfide bond. [UniProt] |
