概述

产品描述	Rabbit Polyclonal antibody recognizes SPHK1
反应物种	Hu, Ms
预测物种	Rat
应用	FACS, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	SPHK1
抗原物种	Human
抗原	Synthetic peptide of Human SPHK1.
偶联标记	Un-conjugated
別名	SK 1; SPK 1; EC 2.7.1.91; SPHK; Sphingosine kinase 1

应用说明

应用建议	应用 推荐稀释比 FACS 1:50 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	Raji
实际分子量	~ 53 kDa

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 20698 Mouse SPHK1 GeneID: 8877 Human SPHK1 Swiss-port # Q8CI15 Mouse Sphingosine kinase 1 Swiss-port # Q9NYA1 Human Sphingosine kinase 1
基因名称	SPHK1
全名	sphingosine kinase 1
背景介绍	The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
生物功能	Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. [UniProt]
细胞定位	Cytoplasm. Nucleus. Cell membrane. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner. [UniProt]
预测分子量	43 kDa

检测图片 (1) Click the Picture to Zoom In