ARG44367
anti-SOX6 antibody
anti-SOX6 antibody for ICC/IF and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SOX6 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SOX6 |
| 抗原物种 | Human |
| 抗原 | Human SOX6 recombinant fusion protein (a.a. sequence: 1-74). |
| 偶联标记 | Un-conjugated |
| 別名 | SOX6; SRY-Box Transcription Factor 6; SRY (Sex Determining Region Y)-Box 6; Transcription Factor SOX-6; SRY-Box 6; SRY-Box Containing Gene 6; HSSOX6; TOLCAS; SOXD |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS, 0.05% Proclin300 and 50% Glycerol. |
| 抗菌剂 | 0.05% Proclin300 |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SOX6 |
| 全名 | SRY-Box Transcription Factor 6 |
| 背景介绍 | This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants. |
| 生物功能 | ranscription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor. |
| 细胞定位 | Cytoplasm, Nucleus |
| 预测分子量 | 92 kDa |
| 翻译后修饰 | Isopeptide bond, Phosphoprotein, Ubl conjugation |
检测图片 (1) Click the Picture to Zoom In
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ARG44367 anti-SOX6 antibody ICC/IF image
Immunofluorescence: U2OS stained with ARG44367 anti-SOX6 antibody at 1:100 dilution.
