ARG41056
anti-SORL1 / SorLA antibody
anti-SORL1 / SorLA antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SORL1 / SorLA |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SORL1 / SorLA |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 2065-2214 of Human SORL1 (NP_003096.1). |
| 偶联标记 | Un-conjugated |
| 別名 | SorLA-1; SorLA; LRP9; LR11; C11orf32; SORLA; gp250; Sorting protein-related receptor containing LDLR class A repeats; LDLR relative with 11 ligand-binding repeats; Sortilin-related receptor; Low-density lipoprotein receptor relative with 11 ligand-binding repeats |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HepG2 | ||||
| 实际分子量 | 290 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SORL1 |
| 全名 | sortilin-related receptor, L(DLR class) A repeats containing |
| 背景介绍 | This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.[provided by RefSeq, Sep 2010] |
| 生物功能 | Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. Golgi apparatus. Endosome. Secreted. [UniProt] |
| 预测分子量 | 248 kDa |
| 翻译后修饰 | The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG41056 anti-SORL1 / SorLA antibody WB image
Western blot: 25 µg of HepG2 cell lysate stained with ARG41056 anti-SORL1 / SorLA antibody at 1:3000 dilution.
