ARG54988
anti-SOD2 antibody [37CT127.5.11.6]
anti-SOD2 antibody [37CT127.5.11.6] for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody
概述
| 产品描述 | Mouse Monoclonal antibody recognizes SOD2 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 37CT127.5.11.6 |
| 同位型 | IgG1, kappa |
| 靶点名称 | SOD2 |
| 抗原 | Purified His-tagged SOD protein fragment. |
| 偶联标记 | Un-conjugated |
| 別名 | MNSOD; Superoxide dismutase [Mn], mitochondrial; IPOB; EC 1.15.1.1; MVCD6 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Human heart |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P04179 Human Superoxide dismutase [Mn], mitochondrial |
|---|---|
| 基因名称 | SOD2 |
| 全名 | superoxide dismutase 2, mitochondrial |
| 背景介绍 | This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| 生物功能 | Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. [UniProt] |
| 细胞定位 | Mitochondrion matrix. |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody |
| 预测分子量 | 25 kDa |
| 翻译后修饰 | Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity. Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity). |
检测图片 (2) Click the Picture to Zoom In
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ARG54988 anti-SOD2 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human lung carcinoma tissue stained with ARG54988 anti-SOD2 antibody.
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ARG54988 anti-SOD2 antibody WB image
Western blot: 20 µg of Human heart lysate stained with ARG54988 anti-SOD2 antibody at 1:2000 dilution.
