ARG57615
anti-SOCS6 antibody
anti-SOCS6 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SOCS6 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SOCS6 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human SOCS-6. |
| 偶联标记 | Un-conjugated |
| 別名 | STAI4; SOCS4; STATI4; SOCS-4; SOCS-6; CIS4; Suppressor of cytokine signaling 6; CIS-4; Cytokine-inducible SH2 protein 4; SSI4; Suppressor of cytokine signaling 4; HSPC060 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Mouse kidney | ||||||
| 实际分子量 | 70 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O14544 Human Suppressor of cytokine signaling 6 Swiss-port # Q9JLY0 Mouse Suppressor of cytokine signaling 6 |
|---|---|
| 基因名称 | SOCS6 |
| 全名 | suppressor of cytokine signaling 6 |
| 背景介绍 | The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008] |
| 生物功能 | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. [UniProt] |
| 预测分子量 | 60 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG57615 anti-SOCS6 antibody WB image
Western blot: 25 µg of Mouse kidney lysate stained with ARG57615 anti-SOCS6 antibody at 1:1000 dilution.
