ARG44260
anti-SMARCA2 / BRM antibody
anti-SMARCA2 / BRM antibody for ICC/IF and Human
概述
| 产品描述 | Goat Polyclonal antibody recognizes SMARCA2 / BRM |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Rat |
| 应用 | ICC/IF |
| 特异性 | This antibody is expected to recognise both reported isoforms |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SMARCA2 / BRM |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the internal region of Human SMARCA2 / BRM (PSNSQLEIEGNSS) |
| 偶联标记 | Un-conjugated |
| 別名 | SMARCA2; SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member; HBRM; BRM; BAF190; SNF2LA; SNF2L2; SNF2; SWI2; Probable Global Transcription Activator SNF2L2; ATP-Dependent Helicase SMARCA2; BRG1-Associated Factor 190B; Protein Brahma Homolog; Brahma Homolog; SNF2-Alpha; BAF190B; HSNF2a; Sth1p |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P51531 Human Probable global transcription activator SNF2L2 |
|---|---|
| 基因名称 | SMARCA2 |
| 全名 | SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2 |
| 背景介绍 | The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. |
| 生物功能 | Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). |
| 细胞定位 | Nucleus |
| 翻译后修饰 | Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation |
检测图片 (1) Click the Picture to Zoom In
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ARG44260 anti-SMARCA2 / BRM antibody ICC/IF image
Immunofluorescence: HeLa stained with ARG44260 anti-SMARCA2 / BRM antibody at 10 µg/m dilution.
