ARG55109
anti-SLPI antibody
anti-SLPI antibody for ELISA,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Cell Biology and Cellular Response antibody; Immune System antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SLPI |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ELISA, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SLPI |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide (17 aa) within aa. 60-110 of Human SLPI. |
| 偶联标记 | Un-conjugated |
| 別名 | HUSI-1; Antileukoproteinase; WAP4; Protease inhibitor WAP4; ALK1; WAP four-disulfide core domain protein 4; BLPI; MPI; HUSI; Secretory leukocyte protease inhibitor; Seminal proteinase inhibitor; Mucus proteinase inhibitor; HUSI-I; WFDC4; ALP |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Daudi Cell Lysate |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SLPI |
| 全名 | secretory leukocyte peptidase inhibitor |
| 背景介绍 | SLPI Antibody: Secretory leukocyte protease inhibitor (SLPI) is produced at mucosal surfaces, primarily the upper respiratory tract and is thought to play an important role in the antiprotease defense mechanism of the lung. SLPI forms inhibitory complexes with numerous proteolytic enzymes such as neutrophil elastase, and has been shown to possess anti-inflammatory, anti-viral, and antibacterial activities. Its expression in oral epithelial cells is stimulated by HIV-1 gp120, suggesting that SLPI is a component of the oral mucosal response to HIV-1. In peripheral blood monocytes, SLPI can inhibit NF-κB activation by inhibiting IκB degradation in the cytoplasm and competing for NF-κB binding sites in the nucleus. This attenuation of the inflammatory response may also act to suppress liver metastases and other cancer cell invasions, but promote blood-borne metastasis via an invasion-independent pathway. |
| 生物功能 | Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Immune System antibody |
| 预测分子量 | 14 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG55109 anti-SLPI antibody WB image
Western blot: Daudi cell lysate stained with ARG55109 anti-SLPI antibody at (A) 1 and (B) 2 ug/ml dilution.
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ARG55109 anti-SLPI antibody IHC image
Immunohistochemistry: SLPI in mouse lung tissue stained with ARG55109 anti-SLPI antibody at 10 ug/ml dilution.
