ARG46736
anti-SLC8A1 antibody [2H09]
anti-SLC8A1 antibody [2H09] for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Monoclonal antibody [2H09] recognizes SLC8A1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | 2H09 |
| 同位型 | IgG |
| 靶点名称 | SLC8A1 |
| 抗原 | Synthesized peptide of SLC8A1 |
| 偶联标记 | Un-conjugated |
| 別名 | SLC8A1; Solute Carrier Family 8 Member A1; NCX1; Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1; Solute Carrier Family 8 Member 1; Na(+)/Ca(2+)-Exchange Protein 1; Sodium/Calcium Exchanger 1; Na+/Ca++ Exchanger; Na+/Ca2+ Exchanger; CNC |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | 300 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | PBS, 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50 % Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SLC8A1 |
| 全名 | Solute Carrier Family 8 Member A1 |
| 背景介绍 | In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation. |
| 生物功能 | Mediates the exchange of one Ca2+ ion against three to four Na+ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca2+ levels and Ca2+-dependent cellular processes. |
| 细胞定位 | Cell membrane, Membrane |
| 预测分子量 | 109 kDa |
| 翻译后修饰 | Glycoprotein, Phosphoprotein |
