ARG22301
anti-SLC12A1 / NKCC2 antibody
anti-SLC12A1 / NKCC2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SLC12A1 / NKCC2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 特异性 | Detects ~160kDa. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 靶点名称 | SLC12A1 / NKCC2 |
| 抗原物种 | Rat |
| 抗原 | Synthetic peptide around aa. 33-55 (N-terminus) of Rat NKCC2 |
| 偶联标记 | Un-conjugated |
| 別名 | BSC1; potassium; Solute carrier family 12 member 1; Kidney-specific Na-K-Cl symporter; Bumetanide-sensitive sodium-; NKCC2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.09% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Slc12a1 |
| 全名 | solute carrier family 12 member 1 |
| 背景介绍 | This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010] |
| 生物功能 | Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. [UniProt] |
| 细胞定位 | Membrane |
| 预测分子量 | 121 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG22301 anti-SLC12A1 / NKCC2 antibody WB image
Western blot: Rat kidney tissue lysates stained with ARG22301 anti-SLC12A1 / NKCC2 antibody at 1:1000 dilution.
