ARG40510
anti-SLC11A2 / DMT1 antibody
anti-SLC11A2 / DMT1 antibody for ICC/IF,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SLC11A2 / DMT1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SLC11A2 / DMT1 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 262-291 of Human SLC11A2 / DMT1. |
| 偶联标记 | Un-conjugated |
| 別名 | NRAMP2; Divalent cation transporter 1; Natural resistance-associated macrophage protein 2; DMT-1; DMT1; Solute carrier family 11 member 2; NRAMP 2; Divalent metal transporter 1; DCT1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Rat cerebellum |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SLC11A2 |
| 全名 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 |
| 背景介绍 | This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010] |
| 生物功能 | Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria. [UniProt] |
| 细胞定位 | Isoform 2: Cell membrane; Multi-pass membrane protein. Early endosome. Endosome membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Also found in extracellular vesicles different from exosomes. [UniProt] |
| 预测分子量 | 62 kDa |
| 翻译后修饰 | Ubiquitinated by WWP2. N-glycosylated. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG40510 anti-SLC11A2 / DMT1 antibody ICC/IF image
Immunofluorescence: HepG2 cells stained with ARG40510 anti-SLC11A2 / DMT1 antibody (green). DAPI (blue) for nuclear staining.
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ARG40510 anti-SLC11A2 / DMT1 antibody WB image
Western blot: 20 µg of Rat cerebellum lysate stained with ARG40510 anti-SLC11A2 / DMT1 antibody at 1:2000 dilution.
