ARG46485
anti-SKA2 antibody
anti-SKA2 antibody for Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SKA2 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SKA2 |
| 抗原物种 | Human |
| 抗原 | A 15 amino acid synthetic peptide within the last 50 amino acids of human SKA2. |
| 偶联标记 | Un-conjugated |
| 別名 | spindle and kinetochore associated complex subunit 2; SKA2; FAM33A; FAM33A; Spindle and kinetochore-associated protein 2; Protein FAM33A |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -535°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8WVK7 Human Spindle and kinetochore-associated protein 2 Swiss-port # Q9CR46 Mouse Spindle and kinetochore-associated protein 2 |
|---|---|
| 基因名称 | SKA2 |
| 全名 | spindle and kinetochore associated complex subunit 2 |
| 背景介绍 | Enables microtubule binding activity. Involved in attachment of mitotic spindle microtubules to kinetochore and regulation of microtubule polymerization or depolymerization. Located in kinetochore and spindle microtubule. Part of SKA complex. [provided by Alliance of Genome Resources, Jul 2025] |
| 生物功能 | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). [UniProt] |
| 细胞定位 | Cytoplasm; Chromosome; Centromere. [UniProt] |
| 预测分子量 | 14 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt] |
