ARG41748

anti-SIX2 antibody

anti-SIX2 antibody for Western blot and Human,Rat

概述

产品描述 Rabbit Polyclonal antibody recognizes SIX2
反应物种 Hu, Rat
应用 WB
宿主 Rabbit
克隆 Polyclonal
同位型 IgG
靶点名称 SIX2
抗原物种 Human
抗原 Synthetic peptide within aa. 200 to the C-terminus of Human SIX2 (NP_058628.3).
偶联标记 Un-conjugated
別名 Sine oculis homeobox homolog 2; Homeobox protein SIX2

应用说明

应用建议
应用 推荐稀释比
WB1:200 - 1:2000
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 Rat kidney
实际分子量 ~ 32 kDa

属性

形式 Liquid
纯化 Affinity purified.
缓冲液 PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂 0.02% Sodium azide
稳定剂 50% Glycerol
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 10736 Human SIX2

Swiss-port # Q9NPC8 Human Homeobox protein SIX2

基因名称 SIX2
全名 SIX homeobox 2
背景介绍 This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development. [provided by RefSeq, Dec 2008]
生物功能 Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. Also may be involved in limb tendon and ligament development (By similarity). Plays a role in cell proliferation and migration. [UniProt]
细胞定位 Nucleus. [UniProt]
预测分子量 32 kDa

检测图片 (1) Click the Picture to Zoom In

  • ARG41748 anti-SIX2 antibody WB image

    Western blot: 25 µg of Rat kidney lysate stained with ARG41748 anti-SIX2 antibody at 1:1000 dilution.