ARG59711
anti-SIM2 antibody
anti-SIM2 antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SIM2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SIM2 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 342-525 of Human SIM2 (NP_033664.2). |
| 偶联标记 | Un-conjugated |
| 別名 | bHLHe15; Single-minded homolog 2; Class E basic helix-loop-helix protein 15; HMC13F06; HMC29C01; SIM |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | U-251MG | ||||
| 实际分子量 | 56 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SIM2 |
| 全名 | single-minded family bHLH transcription factor 2 |
| 背景介绍 | This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014] |
| 生物功能 | Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | Isoform SIM2: 73 kDa Isoform SIM2S: 64 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG59711 anti-SIM2 antibody WB image
Western blot: 25 µg of U-251MG cell lysate stained with ARG59711 anti-SIM2 antibody at 1:1000 dilution.
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ARG59711 anti-SIM2 antibody WB image
Western blot: 25 µg of HepG2 cell lysate stained with ARG59711 anti-SIM2 antibody at 1:1000 dilution.
